Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/256998154?client_source=feed&format=rss
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Sunday, October 21, 2012
You betcha: Fargo awaits TV version of hit movie
FILE - In this 1996 file publicity photo originally released by Gramercy Pictures, actress Frances McDormand, left, is shown in this scene from the movie "Fargo." When the movie debuted in 1996, many residents in the North Dakota city were not fans of the film?s dark humor, not to mention the heavy accents. But the fame and cash from the movie eventually brought many Fargo residents around. Now, 16 years later, Fargo awaits the debut of a new cable television show by the same name. And many residents are less apprehensive about how their hometown will be portrayed this time around. (AP Photo/Gramercy Pictures, File) NO SALES
FILE - In this 1996 file publicity photo originally released by Gramercy Pictures, actress Frances McDormand, left, is shown in this scene from the movie "Fargo." When the movie debuted in 1996, many residents in the North Dakota city were not fans of the film?s dark humor, not to mention the heavy accents. But the fame and cash from the movie eventually brought many Fargo residents around. Now, 16 years later, Fargo awaits the debut of a new cable television show by the same name. And many residents are less apprehensive about how their hometown will be portrayed this time around. (AP Photo/Gramercy Pictures, File) NO SALES
FARGO, N.D. (AP) ? Ask folks in Fargo what they first thought about the 1996 movie that made their city famous, and some will tell you they were not fans.
Some residents initially didn't appreciate the Coen brothers' dark humor or were offended by the extreme violence and depiction of Scandinavian culture. Not to mention those heavy accents on "you betcha" and "ya sure."
But the fame and cash it brought Fargo eventually brought the city around. Now, 16 years later, Fargo awaits the debut of a new cable television show by the same name, and many residents here are less apprehensive about how their hometown will be portrayed this time around. Just ask Kristin Rudrud.
"Anything the Coen brothers are going to be involved in is going to be brilliant," said Rudrud, 57, who played a supporting role in the movie and has a hankering to promote everything about her hometown. "And they love Fargo. They love this area. So it will be done in a very fun and loving way."
The Oscar-winning film starred Frances McDormand as Marge Gunderson, a pregnant police chief who investigates a series of murders, and William H. Macy as a car salesman who hires two criminals, played by Steve Buscemi and Peter Stormare, to kidnap his wife. In one of the final scenes, Stormare feeds Buscemi's body into a wood chipper.
Though the movie made Fargo a household name for many across the country, it wasn't a sure bet when it premiered at the Fargo Theater in 1996. The theater was quiet inside and some moviegoers were offended, said Margie Bailly, who was executive director of the Fargo Theater at the time. Some residents even walked out.
"Those of us who were laughing were a little lonely," she said.
But locals later warmed up as the film was nominated for seven Academy Awards, and Fargo started to see the benefits from all the publicity. The theater hosted a free Oscar party with a polka band and Jell-O treats that Entertainment Weekly billed as one of the top soirees of the evening.
That event was publicized in several countries, and Fargo cashed in. Donations flowed for the theater's restoration, which dovetailed with plans to revitalize the city's downtown.
Sixteen years later, travelers looking to see the real Fargo still swing through, with many flocking to take a picture next to the iconic wood chipper, autographed on the chute by the Coen brothers and displayed at the city's main tourism center. Tourism staff hand out ear-flap hats to tourists and take pictures of them stuffing the leg of a mannequin into the Yard Shark.
"A good majority of people come in here just looking for the wood chipper," said Jayne Rieth, who works at the tourism center. She didn't like the movie on the big screen, but watched it at home recently so she could be better informed at work. And the tourism center and shops around town sell plenty of wood chipper T-shirts, shot glasses, koozies, mugs and ? of course ? ice scrapers.
City boosters hope the TV show, which will be produced by Minnesota-born filmmakers, Joel and Ethan Coen, will add to the notoriety. No timeline has been announced by the FX Network, and John Solberg, FX's senior vice president of public relations, did not return messages left by The Associated Press.
"I don't know how it can be a bad thing for us," said Charley Johnson, president and CEO of the city's convention and visitor's bureau. "People still talk about the movie all the time."
Larry Gauper, of Fargo, a retired health insurance executive, also thinks most people are looking forward to the TV show.
"There are some people who don't like us sort of being mocked or being made fun of, but I think most people really appreciate the attention Fargo gets," Gauper said.
But Fargo movie fan Marnie Piehl wonders if the city has changed too much ? thanks to population growth and a revitalized downtown with high-end restaurants and bars serving craft beer and organic vegetables ? that it no longer makes sense to situate the TV show here. McDormand's character would have left Fargo years ago, Piehl said.
"That may sound funny to someone from New York, but it just doesn't fit for me anymore," she said. "The North Dakota story is not the Marge Gunderson story anymore."
Though details about the plot and characters in the FX show are scant, that hasn't many stopped Fargo residents from speculating about it.
Mayor Dennis Walaker said his favorite character is the sheriff, and hopes McDormand gets a prominent role. And although Rudrud's character, Macy's wife, was killed off in the movie, she joked that there might be room for her in the adaptation.
"Well, I haven't been chopped up," she said. "There's always a possibility."
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Miller hurt in Buckeyes' victory over Purdue
COLUMBUS, Ohio (AP) ? Ohio State quarterback Braxton Miller was hurt late in the third quarter of the seventh-ranked Buckeyes' victory over Purdue on Saturday.
Team spokesman Jerry Emig confirmed that the sophomore had been taken to the hospital and was being evaluated. He did not say what the nature of the injury was or its severity.
In his postgame remarks after Ohio State's 29-22 overtime win, coach Urban Meyer said he didn't know Miller's exact injury or his status.
"I think it's (his) head and that concerns all of us," he said.
Miller, mentioned among the top Heisman Trophy contenders, was at the end of a 37-yard run when he was thrown to the turf by cornerback Josh Johnson.
Miller didn't get up for several minutes ? he was in obvious pain ? while he was attended by several doctors and trainers. Eventually he sat up, then stood on shaky legs for at least 60 seconds before he was led to the sidelines. He was later taken to the locker room by cart.
Miller completed 9 of 20 passes for 113 yards with an interception and ran for 47 yards on 12 carries before leaving the game.
His replacement, Kenny Guiton, led Ohio State to a touchdown with 3 seconds left, then after that scoring pass also threw a two-point conversion pass to send the game into overtime.
In the overtime, Carlos Hyde scored on a 1-yard plunge for the Buckeyes before Purdue failed to complete any of its four passes.
Source: http://news.yahoo.com/miller-hurt-buckeyes-victory-over-purdue-203744378--spt.html
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Saturday, October 20, 2012
If The Health Care Industry Married Silicon Valley, They'd Have ...
I just got back to San Francisco from the 15-year celebration of LIVESTRONG, the Lance Armstrong Foundation. It was an interesting time to be in Austin, as most of the world is still shell-shocked from Armstrong stepping down as the Chairman due to outside pressure from his doping scandal. However, most people had a positive attitude when it comes to the direction that LIVESTRONG is going in, but there?s definitely room for improvement.
Cancer is just one of the diseases that needs better treatment and a cure. While I was in Austin, I thought a lot about my smart friends back in Silicon Valley and all of the hard problems that they?re solving in their daily jobs at startups or companies like Facebook and Google. Those thoughts led me to wonder what would happen if you put all of those brilliant people into a room together to ?hack a cure.? I?m talking about all-in stuff here, not a conference or chat ?once in a while.?
I know that there are a lot of health care companies out here who are already helping patients access their records, interface with doctors and improve their experience battling a wide range of illnesses. There?s also companies like 23andMe who are mapping our DNA to try and help direct us to preventative health care.
I love it, but we can do more, can?t we? Celebrities are getting involved in charitable causes, and that?s cool. It helps spread more awareness for important things. There?s a place for geeks in this equation.
If the health care industry could ship information as quickly as Facebook ships code on its site, and with the same passion as Zuckerberg?s crew, I think that we could do some real damage when it comes to lengthening our lives and improving health care overall. Why hasn?t it been done yet, though? Health care isn?t a sexy industry. Neither is education, sadly.
?What?s Hot? is Getting Old
When I look at my inbox and see thirty new photo-taking apps, I get really frustrated. Not because people aren?t trying hard, but that we?re stuck on solving the same ?problem?, which really wasn?t a problem in the first place, over and over again. Too much time, creativity and money is being spent on buying short domain names, beautiful interfaces and a business model that might help you raise a buck or two. But what comes after that?
Not everyone is going to sell to Facebook. Trust me.
What if the folks who are working really hard on copying things that are already successful forked over to a new set of problems, like the medical industry, health care or education? Sure, it?s not ?sexy?, and sure you won?t get 20M users and lots of press coverage, but engineers who are experienced in moving and computing massive amounts of data could actually stumble onto a breakthrough accidentally. That?s how clinicians and doctors find cures and new drugs. Trial and error.
What if Silicon Valley Paired up With Doctors?
That trial and error approach from the medical industry, with creative tactics to solve complex problems from Silicon Valley, is exactly what?s missing in the world right now.
While I was in Austin I spoke to many folks who volunteer at LIVESTRONG and I asked them what we?re lacking in cancer research and support right now. Most of them said ?technology.? They don?t mean apps, they mean they need the brains, passion and manpower of the best place to kick thing?s ass in the world. That?s Silicon Valley.
Sure, a lot of folks who have flipped companies have given money to charity, and that?s great. Really, it?s awesome to support a charity you care about, even if its not LIVESTRONG. But what?s more important than money is time. There?s only so much time on this planet to do things, and if you don?t have enough people doing them, you have yourself a time shortage.
That means it?s like that you, the reader, will be affected by some nasty illness or disease at some point in your life. It?s scary to think about, but it doesn?t have to be. We have a real opportunity in this information age to make a difference.
No more talking
Maybe the whole health care industry needs to wise up and reach out to the Valley too. Maybe they should open their doors to smart people in flip-flops more often. Hold a hackathon for good, and not worry about being out-smarted by someone who doesn?t have the degree, experience or credentials that they have.
See, to do really amazing things, sometimes you need to suck it up and just do it.
I honestly believe that a cure for cancer will be assisted largely in part by a new breed of technologist, one who doesn?t care about the glitz and glamor of being a ?Silicon Valley Rock Star?, but one that truly wants to change the world.
Let?s do something. Geeks, meet Doctors. Doctors, meet Geeks. Go have babies named ?Cure.? It ain?t sexy, but it could save our lives.
(Just in case you?re wondering what action I?m going to take, I am working with LIVESTRONG to bridge the gap between Austin and Silicon Valley. In fact, I?ll be pitching some big companies on doing a few meetups and hackathons in the coming future. I need some help though.)
LIVESTRONG.com is a health and wellness site to be launched in mid 2008. The site aims to provide visitors with a range of health related content, including actionable and personal online tools and professional health, wellness and fitness related information. The site is a partnership between Demand Media and the Lance Armstrong Foundation.
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Mathematics Journal Approves Paper Filled With Computer-Generated Gibberish Equations
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Friday, October 19, 2012
New fruit fly model of epilepsy reveals mechanisms behind fever-induced seizures
Thursday, October 18, 2012
UC Irvine and Brown University researchers have created a new fruit fly model of inherited epilepsy that's providing insights into the mechanisms underlying temperature-dependent seizures while establishing a platform from which to develop therapies for these disorders.
In the Oct. 10 issue of The Journal of Neuroscience, Diane O'Dowd of UCI, Robert Reenan of Brown and colleagues report their method for placing a gene mutation that causes human fever-induced seizures into drosophila fruit flies. As a result, the mutant flies experience heat-induced seizures.
This represents the first time a human genetic disease mutation has been "knocked in" to the equivalent location in the fruit fly genome. The drosophila knock-in model provides a rapid and low-cost basis for defining the neural mechanisms contributing to inherited seizure disorders.
"We can also use this genetic model of human epilepsy in fruit flies to look for new treatments for the disease," said O'Dowd, professor and chair of developmental & cell biology at UCI.
Fever-induced, or febrile, seizures are most commonly seen in children. Only about one in 100 children with febrile seizures develops epilepsy, and most outgrow them by age 5. In contrast, individuals who have the inherited disorder ? termed GEFS+ ? have febrile seizures that persist beyond childhood and also often develop seizures in the absence of fever.
Reenan, a biology professor at Brown, and Brown undergraduate Jeff Gilligan used a genetic-exchange research method called "homologous recombination" to insert a mutation into the gene in fruit flies that's a direct parallel of the GEFS+ mutation in the human SCN1A sodium channel gene that causes febrile seizures in people.
When placed in tubes that were put in warm water, most of the mutant fruit flies began to experience seizures within 20 to 30 seconds. They would fall over, and their wings would flap and their legs twitch for about two minutes while the flies were kept at a high temperature. The researchers found that seizure susceptibility was dose-dependent: Ninety-five percent of the flies with two copies of the mutant gene had seizures, as opposed to 60 percent of those with just one copy. Unaltered control flies did not have temperature-dependent seizures.
To determine the neurological causes of the seizures, O'Dowd, her postdoctoral fellow and lead study author Lei Sun, and UCI colleagues examined neurons in the brains of both mutant and control flies to monitor activity and see how they behaved as the brains were heated. In the mutant flies, they discovered flaws in the functioning of sodium channels.
"What happens is the mutant channels don't open and close properly," O'Dowd said. "This effect is amplified at high temperature, and this changes the ability of neurons to generate the appropriate electrical signals, leading to hyperactivity in the brain circuits."
"With this knowledge, the next step is to use this model to look for drugs that might reduce or eliminate heat-induced seizures," she added.
In addition to providing insight into the neurology of febrile seizures, the study establishes a new fruit fly model as a viable genetic platform for the study of epilepsy and validates the use of homologous recombination in flies to explore mechanisms underlying other genetically linked diseases.
###
University of California - Irvine: http://www.uci.edu
Thanks to University of California - Irvine for this article.
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