Monday, February 11, 2013

No. 25 Irish outlast No. 11 Cards 104-101 in 5 OTs

Essential News from The Associated Press

AAA??Feb. 10, 2013?2:20 AM ET
No. 25 Irish outlast No. 11 Cards 104-101 in 5 OTs
By TOM COYNEBy TOM COYNE, Associated Press?THE ASSOCIATED PRESS STATEMENT OF NEWS VALUES AND PRINCIPLES?

Notre Dame forward Tom Knight (25) celebrates with Leprechaun Bryce Burton following an NCAA college basketball game against Louisville, Saturday, Feb. 9, 2013, in South Bend, Ind. Notre Dame won 104-101 in five overtimes. (AP Photo/Joe Raymond)

Notre Dame forward Tom Knight (25) celebrates with Leprechaun Bryce Burton following an NCAA college basketball game against Louisville, Saturday, Feb. 9, 2013, in South Bend, Ind. Notre Dame won 104-101 in five overtimes. (AP Photo/Joe Raymond)

Notre Dame guard Pat Connaughton shoots in overtime of their NCAA college basketball game against Louisville, Saturday, Feb. 9, 2013, in South Bend, Ind. Notre Dame won 104-101 in five overtimes. (AP Photo/Joe Raymond)

Notre Dame players including Zach Auguste, center right, and Jack Cooley, center left, celebrate with fans after their 104-101 win over Louisville in the fifth overtime of their NCAA college basketball game, Saturday, Feb. 9, 2013, in South Bend, Ind. (AP Photo/Joe Raymond)

Notre Dame guard Jerian Grant, left, drives against Louisville guard Wayne Blackshear during the first half of an NCAA college basketball game, Saturday, Feb. 9, 2013, in South Bend, Ind. (AP Photo/Joe Raymond)

Notre Dame guard Eric Atkins, right, attempts to drive to the basket as Louisville guard Peyton Siva defends during the first half of an NCAA college basketball game, Saturday, Feb. 9, 2013, in South Bend, Ind. (AP Photo/Joe Raymond)

(AP) ? Cameron Biedscheid scored on a layup with 1:19 left in the fifth overtime, and Eric Atkins and Pat Connaugton added free throws in the final 19 seconds as No. 25 Notre Dame overcame an eight-point deficit in regulation to beat No. 11 Louisville 104-101 Saturday night.

Russ Smith had a chance to tie it, but his 3-point attempt missed before Notre Dame students flooded the court to celebrate. It marked the sixth time in the last eight meetings that a game between the Fighting Irish (19-5, 7-4 Big East) and the Cardinals (19-5, 7-4) went into overtime.

Both teams missed crucial free throws in the final minute. Atkins missed two with 37 seconds left and Montrezi Harrell did the same for Louisville with 24 seconds left.

Jerian Grant, who fouled out with 1:57 left in the first overtime, led the Irish with 19 points.

Chane Behanan had 30 points and 15 rebounds for Louisville.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-02-10-BKC-T25-Louisville-Notre-Dame/id-96b93a8bfea6460cac435c44c008d964

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Sunday, February 10, 2013

Lymphoma Cells Selectively Destroyed By Experimental Drug ...

Laboratory experiments conducted by scientists at Virginia Commonwealth University Massey Cancer Center suggest that a novel combination of the drugs ibrutinib and bortezomib could potentially be an effective new therapy for several forms of blood cancer, including diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL).

The study, published in the British Journal of Hematology, showed that the experimental drug combination killed cancer cells through a form of cell suicide known as apoptosis, but was relatively non-toxic to normal, healthy cells. Ibrutinib is a new agent that inhibits the B-cell receptor (BCR) signaling complex, which plays an important role in the survival of malignant B-cells. It has shown very promising initial results in the treatment of patients with B-cell malignancies, including chronic lymphocytic leukemia (CLL), DLBCL and MCL. The synergistic interaction of the two drugs proved lethal even to lymphoma cells that had become resistant to bortezomib, when used alone.

?Bortezomib is currently used to treat MCL and multiple myeloma, but, unfortunately, many patients develop resistance to the drug,? says the study?s principle investigator Steven Grant, M.D., Shirley Carter Olsson and Sture Gordon Olsson Chair in Oncology Research, associate director for translational research, program co-leader of Developmental Therapeutics and Cancer Cell Signaling research member at VCU Massey Cancer Center. ?We are hopeful that this combination therapy may circumvent such resistance and eventually help fill an urgent need for more effective therapies for patients with these uncommon blood disorders.?

With cultured DLBCL and MCL cells in laboratory experiments spearheaded by Girija Dasmahapatra, Ph.D., lead author of the study?s manuscript and instructor in the Department of Internal Medicine at VCU School of Medicine, the scientists found that ibrutinib blocked several molecular pathways that the cancer cells use for growth and survival. When ibrutinib was combined with bortezomib, the scientists observed a high level of synergism between the two drugs that resulted in profound cell death due to DNA damage, culminating in apoptosis. The research findings suggest that the effectiveness of the combination therapy against bortezomib-resistant lymphoma cells may stem from ibrutinib?s ability to block signaling pathways used by the cancer cells to survive bortezomib exposure.

Specifically, exposure of DLBCL and MCL cells to ibrutinib blocked the cancer-promoting NF-?B, AKT and ERK1/2 signaling pathways. These signaling pathways provide cells with the ability to adapt to otherwise harmful environmental stimuli by transmitting messages from receptors located at the cell?s surface to proteins within the cell that trigger a variety of biological processes. In particular, NF-?B, AKT and ERK1/2 have been shown to carry out many functions that allow cancer cells to survive and proliferate. Significantly, each of these pathways has been implicated in the development of resistance to proteasome inhibitors such as bortezomib.

?We have provided a framework for understanding how an agent like ibrutinib might be employed to enhance the activity of an established anti-cancer agent like bortezomib,? says Grant. ?We are currently working with representatives from the pharmaceutical industry and the National Cancer Institute to develop a new treatment strategy in which ibrutinib will be combined with proteasome inhibitors like bortezomib for the treatment of patients with lymphomas and potentially other blood cancers.?

Article adapted by Medical News Today from original press release. Click ?references? tab above for source.
Visit our lymphoma / leukemia / myeloma section for the latest news on this subject. Grant and Dasmahapatra collaborated on this study with Hiral Patel and Tri Nguyen, Ph.D., from the Department of Internal Medicine at VCU School of Medicine; Paul Dent, Ph.D., Universal Corporation Distinguished Professor for Cancer Cell Signaling, vice chair of the department of neurosurgery and member of the Developmental Therapeutics research program at VCU Massey; and Richard I. Fisher, M.D., and Jonathan Friedberg, M.D., from the James T. Wilmot Cancer Center at the University of Rochester.

This research was supported by National Institutes of Health grants CA63753, CA93738 and CA100866; Lymphoma SPORE award 1P50 CA130805; award R6059-06 from the Leukemia and Lymphoma Society of America; the Multiple Myeloma Research Foundation; Myeloma Spore grant P50CA142509; the V Foundation; and, in part, by funding from VCU Massey Cancer Center?s NIH-NCI Cancer Center Support Grant P30 CA016059.

Virginia Commonwealth University

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'This is it': Mammoth winter storm hits Northeast

By Erin McClam and Kari Huus, NBC News

Updated at 3:15 a.m. ET: A powerful winter storm pounded the Northeast Saturday, with gusting winds and heavy snow causing power failures for hundreds of thousands of people, dozens of accidents and fuel shortages at gas stations.?

At least one death was confirmed, a snow-related car accident in Poughkeepsie, N.Y.

By midnight ET, 19 inches of snow had fallen at Mount Sinai on New York's Long Island and 18.5 inches at Manchester, Conn., weather.com reported.

In Massachusetts, gusts over 50 mph were reported in Boston and over 60 mph on Nantucket Island. Winds up to 75 mph were possible in Provincetown, forecasters said.

Police said hundreds of cars were stuck on the Long Island Expressway, NBC weatherman Al Roker said in a message on Twitter.

The winter storm gathered strength as two weather systems ? a so-called clipper pattern sweeping across the Midwest and a band of rain from the South ? converged over the Northeast early Friday.

By late Friday, the storm had arrived in earnest and was expected to pummel New England through Saturday and last as long as Sunday farther north.

Governors of New York, New Hampshire, Connecticut, Massachusetts and Rhode Island?declared states of emergency.?

More than 800 National Guard soldiers and airmen were activated in Connecticut, Massachusetts and New York to provide roadway support, emergency transportation and back-up for first responders, the Department of Defense said Friday evening, while governors in the region warned people to get home and be prepared?for power outages.

Airlines canceled more than 3,000 flights on Friday, Boston closed its subway, Amtrak suspended some service, and cities across the Northeast prepared to deploy an armada of snowplows and salt-spreading trucks.

More than half a million people were without power, including a whopping 389,000 customers in Massachusetts, 177,000 in Rhode Island?and?35,000 in Connecticut, and more power failures were expected overnight.?

For people in the blizzard?s path, forecasters and authorities had a clear message: Stay home.

Driving bans
Governors in Connecticut, Rhode Island and Massachusetts announced restrictions on driving.

In the most sweeping ban, Massachusetts Gov. Deval Patrick ordered?all non-essential vehicles off the roads by 4 p.m. and said people should brace to be snowed in for two days. He said the storm was "profoundly different" from others?the state?has endured in recent years.

Gov. Dannel Malloy?of Connecticut banned car traffic on limited-access highways starting at 4 p.m. State police reported nearly 100 minor accidents across the state by Friday afternoon.

"If you don't currently have a reason to be on the road, if you're not an emergency personnel that's required to report to work somewhere, stay home," Malloy said at a state armory news conference. "This is it. Things are starting to accumulate."

In the Poughkeepsie, N.Y. crash, a car driven by an 18-year-old female went out of control in the snow and struck Muril M. Hancock, 74, who was walking near the shoulder, police said. Hancock died from his injuries at the hospital.

The eastern part of Connecticut was experiencing white-out conditions late into the evening, the state's emergency operations center reported, and even snowplows were immobilized because of the weather.

Several motorists were reported stranded on snowed-in highways and interstates, but no injuries had been reported. Still, emergency crews were unable to respond due to the severe conditions.

A 19-car pileup on Interstate 295 in Falmouth, Maine, was blamed on the storm. Police said there were minor injuries.

Forecasters said they expected Massachusetts to get the most snowfall,?with an?accumulation of up to 3 feet in some spots. The worst snowfall on record in Boston was a 27.5-inch blast a decade ago.

Near-hurricane force winds
The Weather Channel said forecast as much as 2 feet of snow in Hartford, Conn., and as much as 15 inches in New York.

Coastal residents were warned that the winds could top 70 mph.

Those living on north- and east-facing shorelines from Boston south to Cape Cod Bay were told to prepare for tides 2 to 4 feet above normal.

"Coastal flooding is expected on the Maine, New Hampshire and Massachusetts coastlines," the National Weather Service said.

"I'm really nervous," Kathy Niznansky, a 65-year-old teacher in coastal Fairfield, Conn. told The Associated Press. Niznansky is still recovering from flooding from Superstorm Sandy which arrived on her birthday and?knocked her out of her house near the beach for two months. "Now I'm really worried about this tide tonight. I just don't want any more flooding."

Elsewhere, Rhode Island police asked people for loaner snowmobiles, and out-of-state utility crews headed for Connecticut to help.

Full coverage from The Weather Channel
Watch live video of the Northeast blizzard
?Sandy survivors: It's like a repeat 'nightmare'??

Airline cancellations piled up all morning. Almost 3,000 flights were scrapped for Friday and more than 1,000 more for Saturday, according to FlightAware.com.

At the major airports in New York and New England, most major airlines said they would shut down completely Friday afternoon.

Schools were closed in Boston and for most of New England on Friday. Patrick ordered non-essential state workers to stay home Friday and encouraged private employers to do the same.

In New York, the transit agency added more than 20 afternoon trains on its Metro-North commuter line from Grand Central Terminal to get people out of the city before the worst hit.

The Metro-North suspended service Friday night due to the storm. The Long Island Rail Road shut down service east of Speonk about 9 p.m.

Mayor Michael Bloomberg warned people to stay in and to use public transportation if they had to go out, although even that carried the possibility of disruptions. The city had 250,000 tons of salt at the ready for the roads.

He encouraged New Yorkers to stay in and cook a meal or read a good book.

"This is a very serious storm, and we should treat it that way," said Tom Prendergast, president of the agency that runs New York subways and buses.

The weather service warned that the combination of heavy snow and high winds would limit visibility and cause whiteout conditions at times.

"Those venturing outdoors may become lost or disoriented," the weather service said in an advisory issued for the Boston area.

The Associated Press contributed to this report.

Related:

The Weather Channel live stream

The Weather Channel live blog

State-by-state impact of the storm

Current conditions

Show us your storm photos by adding #NBCNewsPics to your tweet or Instagram post, or upload your pictures directly by clicking the box below.

Source: http://usnews.nbcnews.com/_news/2013/02/08/16895255-whiteout-potentially-historic-winter-storm-closes-in-on-northeast?lite

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The week's best of the internet

The 8 best images, memes, videos, and more to emerge from the great digital playground ? from unflattering photos of Beyonc? to the worst lie ever caught on camera

1. Score one for Bing?
Wired's Danger Room blog thinks it uncovered the United States' alleged drone base hidden in the Saudi Arabian desert. How did Wired find it? Surprisingly, using Bing Maps ? the satellite images were nowhere to be found on Google. "The images show a trio of 'clamshell'-style hangars, surrounded by fencing. Each is more than 150 feet long and approximately 75 feet wide; that's sufficient to hold U.S. Predator and Reaper drones," writes Wired's Noah Shachtman. See?for yourself.

2. Tumblr of the Week: WTF, Evolution?
This delightful Tumblr?showcases some of the stranger creatures put on God's green ? HOLY COW WHAT IS THAT THING?

SEE ALSO: Mailbox for iPhone: Finally, email done right?

3. Breaking Bad Kitty
Is that you, Mr. White? (Via E Online)

SEE ALSO: Why Vine will be as revolutionary as Twitter was

(Instagram/George the cat)

4. Liar liar, pants on fire
Well this is adorable. This little guy tells his mom he didn't eat any of the sprinkles when there are clearly sprinkles all over his face! Ha ha. Hide the evidence better next time, kid. Or better yet, stop lying. (Via ClipNation)

SEE ALSO: Pay to play

5. Unflattering photos of?Beyonc??
The internet loves Beyonc?. That's what the "B" in?Buzzfeed?stands for. (What, you didn't know?) That's also why it was a bit strange when Queen B's publicist emailed the website's editors asking them to remove a few of the star's more "unflattering" images taken during her Super Bowl halftime show. Instead of complying, Buzzfeed decided to get weird with it. (Via Buzzfeed)

SEE ALSO: James Dyson and the bright future of hand-washing

6. This is what Winter Storm?Nemo looks like?
...from outer space. (Via NASA)

SEE ALSO: The first panorama from the top of the world's tallest building

7. Another great Tumblr: OK Cupid e-books
This is what happens when you respond to persistent suitors on dating site OK Cupid using only quotes from the semi-automated Twitter account?@Horse_ebooks. (Via Tumblr)

SEE ALSO: Was the news of Instagram's?decline greatly exaggerated?

8. Cat of the Week
Say what's up to Cyrus from Washington D.C. Apparently, he and I share an affinity for The Fast and the Furious. (Thanks, Heather!)

SEE ALSO: Why Chinese hackers stole the passwords of?New York Times employees

Send your "Cat of the Week" submissions to:?Gayomali@theweek.com.

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Source: http://news.yahoo.com/weeks-best-internet-153300760.html

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Saturday, February 9, 2013

Histone modification controls development: Chemical tags on histones regulate gene activity

Feb. 8, 2013 ? Every gene in the nucleus of an animal or plant cell is packaged into a beads-on-a-string like structure called nucleosomes: the DNA of the gene forms the string and a complex of proteins called histones forms the beads around which the DNA is wrapped. Scientists of the Max Planck Institute of Biochemistry in Martinsried near Munich, Germany, have now established that adding chemical tags on histones is critical for regulating gene activity during animal development.

Studies over the past two decades revealed that many proteins that control the activity of genes are enzymes that add small chemical tags on histone proteins but also on a variety of other proteins. With their studies the researchers have now shown that it is the tags on the histones that control if genes are active or inactive.

Their results were published in the journal Science.

Histone proteins can be modified by a number of different chemical tags at very specific sites. The researchers in the Research Group 'Chromatin Biology' of J?rg M?ller focused on the histone tag that is added by an enzyme called Polycomb Repressive Complex 2 (PRC2). PRC2 is essential for a variety of different cell fate decisions in animals and plants. PRC2 functions to keep genes inactive in cells and at times where they should remain inactive.

Using the model organism Drosophila -- the fruit fly -- the scientists now generated animals with cells expressing an altered histone protein to which PRC2 can no longer add the tag. These cells cannot keep genes inactive anymore and many cell fate decisions go awry, exactly like in cells that lack the PRC2 enzyme.

"This observation demonstrates that the business end is the tag on the histone and not on some other protein" says Ana Pengelly, the PhD student who conducted the experiments. Her colleague Omer Copur adds: "The approach we used permits us to now also investigate the function of other tags on histone proteins that have a different chemical nature." The insight gained from the work on PRC2 provides a strong impetus to figure how this tag alters the beads-on-a-string structure of genes and thereby controls gene activity.

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The above story is reprinted from materials provided by Max Planck Institute of Biochemistry.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. A. R. Pengelly, O. Copur, H. Jackle, A. Herzig, J. Muller. A Histone Mutant Reproduces the Phenotype Caused by Loss of Histone-Modifying Factor Polycomb. Science, 2013; 339 (6120): 698 DOI: 10.1126/science.1231382

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/tbXY1RBPY6s/130208105720.htm

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Kids rewarded for good manners at Wash. restaurant

This photo provided by Laura King shows a receipt for dinner at Sogno di Vino in Kingston, Wash. To Laura King, her three children were acting normal while enjoying dinner at the Italian restaurant in their hometown in Washington state. But staffers of the restaurant were so impressed at her children's table manners that they thanked her kids and gave the family of five a bowl of ice cream. It wasn't until King got home that that she noticed a $4 "well-behaved kids" discount on her receipt to cover the dessert. (AP Photo)

This photo provided by Laura King shows a receipt for dinner at Sogno di Vino in Kingston, Wash. To Laura King, her three children were acting normal while enjoying dinner at the Italian restaurant in their hometown in Washington state. But staffers of the restaurant were so impressed at her children's table manners that they thanked her kids and gave the family of five a bowl of ice cream. It wasn't until King got home that that she noticed a $4 "well-behaved kids" discount on her receipt to cover the dessert. (AP Photo)

This photo provided by Laura King shows the King family, from left, Chris, Miles, Sydney, Laura and Elle. To Laura King, her three children were acting normal while enjoying dinner at the Italian restaurant in their hometown in Washington state. But staffers of the restaurant Sogno di Vino in Kingston were so impressed at her children's table manners that they thanked her kids and gave the family of five a bowl of ice cream. It wasn't until King got home that that she noticed a $4 "well-behaved kids" discount on her receipt to cover the dessert. (AP Photo)

SEATTLE (AP) ? To Laura King, her three children were acting normal while enjoying dinner at an Italian restaurant in their hometown in Washington state.

But staffers of the restaurant Sogno di Vino in Poulsbo were so impressed with her children's table manners during their Feb. 1 dinner that they thanked her kids and gave the family of five a bowl of ice cream.

It wasn't until King got home that that she noticed a $4 "well behaved kids" discount on her receipt to cover the dessert. A friend posted a picture of the receipt on the website Reddit, and the story took off.

"The server said staff didn't even know there were kids at the table," said King, whose children are 2, 3, and 8 years old.

King said it's been entertaining to see all the attention her story has gotten, and she plans to dine at Sogno di Vino again soon.

Sogno di Vino owner Rob Scott said servers have the discretion to offer a discount to customers, adding that this wasn't the first time well-behaved kids have been rewarded. What was different this time was that one of the staffers wrote it out in the receipt.

"It was just an act of kindness," Scott said.

Scott said the restaurant was packed the night Laura's family came in, which can be challenging to families with small children. But he said he was impressed with the way the family was interacting with each other and that even the 2-year-old on a high chair seemed to be having a good time.

Rowdy children are an issue all restaurant customers have encountered at one point or another, Scott said.

"You can tell when a (family) had a rough ride to the restaurant," Scott said. "There tends to be sometimes activities where children get out of the chair or stand on chairs or get loud, as they get loud, it upsets other patrons, and they paid for a baby sitter."

Scott said he's been asked if he would charge more to customers who have unruly children. That's not something he does, he said.

"Everybody in my generation was raised to behave in restaurants," he said. "That parenting skills have been forgotten in some cases."

King said she has worked in the restaurant industry before and knows that families aren't the easiest customers to serve. She said that at the restaurant, her kids apply the table etiquette used at her dining table.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/aa9398e6757a46fa93ed5dea7bd3729e/Article_2013-02-08-Good%20Behavior%20Discount/id-c402cc72a15647c59b6426c0085bf5c0

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Bishops criticize Obama administration for birth control requirement (Washington Bureau)

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